Platelet adhesion to dimeric β2-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibαand apolipoprotein E receptor 2′
نویسندگان
چکیده
منابع مشابه
Glycoprotein Ib –Mediated Platelet Adhesion and Aggregation to Immobilized Thrombin Under Conditions of Flow
Objectives—Thrombin interacts with platelets via the protease-activated receptors (PARs) 1 and 4, and via glycoprotein Ib (GPIb ). Recently, it was shown that platelets are able to adhere to immobilized thrombin under static conditions via GPIb . Methods and Results—Here, we show that platelets are also able to adhere to and form stable aggregates on immobilized thrombin under conditions of flo...
متن کاملGlycoprotein Ibalpha-mediated platelet adhesion and aggregation to immobilized thrombin under conditions of flow.
OBJECTIVE Thrombin interacts with platelets via the protease-activated receptors (PARs) 1 and 4, and via glycoprotein Ibalpha (GPIbalpha). Recently, it was shown that platelets are able to adhere to immobilized thrombin under static conditions via GPIbalpha. METHODS AND RESULTS Here, we show that platelets are also able to adhere to and form stable aggregates on immobilized thrombin under con...
متن کاملPlatelet adhesion to collagen and endothelial cell matrix under flow conditions is not dependent on platelet glycoprotein IV.
Platelet membrane glycoprotein IV (GPIV) is a cell-surface glycoprotein that has been proposed as a receptor for collagen. Recently, it has been shown that platelets with the Naka-negative phenotype lack GPIV on their surface, whereas donors with this phenotype are healthy and do not suffer from hematologic disorders. In this study, we compared Naka-negative platelets with normal platelets in a...
متن کاملOptimization of Unnicked β2-Glycoprotein I and High Avidity Anti-β2-Glycoprotein I Antibodies Isolation
Patient biological material for isolation of β2-glycoprotein I (β2GPI) and high avidity IgG anti-β2-glycoprotein I antibodies (HAv anti-β2GPI) dictates its full utilization. The aim of our study was to evaluate/improve procedures for isolation of unnicked β2GPI and HAv aβ2GPI to gain unmodified proteins in higher yields/purity. Isolation of β2GPI from plasma was a stepwise procedure combining n...
متن کاملRole of glycoprotein IIb:IIIa in the adhesion of platelets to collagen under flow conditions.
To the Editor: can be easily explained. Platelet adhesion to collagen is sensitive to the presence of Mg-ions. The adhesive properties of VLA-2 (GPIa:IIa), the major collagen receptor on the platelet membrane, are In their interesting report, Moroi et al studied the adhesion of platelets to a collagen-coated surface and they described, among dependent on Mg. In the presence of physiologic conce...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2007
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2007.02310.x